As the biopharma landscape grows in complexity, MSLs are taking on more complex roles. They are charged with the dual responsibility of gathering insights and disseminating data-driven messages that can influence a range of internal strategies, including clinical development, marketing, and market access strategies. Their presence in the clinical practice is pivotal in enhancing patient treatment outcomes.
Through their close collaboration with Healthcare Professionals (HCPs) and the Key Opinion Leaders (KOLs), MSLs acquire a deep understanding of clinical practice in addition to understanding the latest trends and need in the healthcare sector. This knowledge is then channeled back to pharmaceutical companies creating a vital link between scientific research and practical applications. This unique position empowers MSLs to contribute to the creation of innovative therapies that can dramatically enhance the therapeutic landscape.
In specialized fields such as rare diseases and specialty care where personalized medicines and innovative treatment methodologies are abundant, the role of MSLs is particularly significant. With a limited number of specialists in these areas, the role of MSLs is evolving to meet the changing needs of the healthcare landscape. They are becoming indispensable for their expertise in communicating complex scientific information, enhancing patient treatment outcomes, and crafting personalized content based on field insights.
Understanding and Addressing the Unique Needs of KOLs
In the dynamic world of KOLs and expert groups, the landscape is evolving due to generational shifts and technological advancements. As these influencers wield significant power in shaping public opinion and driving trends, understanding their unique needs and perspectives becomes paramount. This understanding not only fosters effective communication but also enables the development of strategies that resonate with their values and aspirations, thereby ensuring a mutually beneficial relationship.
KOLs are showing a strong preference for medical content that is tailored to their professional interests, historical endorsement patterns, their influence scope, and their understanding of different medical breakthroughs. This trend underscores the importance of a nuanced understanding of the diverse motivational drivers and communication preferences across different KOL segments. This approach ensures that the information provided is not only relevant but also impactful, fostering a deeper engagement between MSLs and the KOLs confirming the shift in landscape towards a more personalized and targeted approach in engaging with KOLs.
The Power of Personalized Content in MSL-KOL Engagement
Personalized content is a major value proposition that MSLs can provide, especially when done with consideration of KOL objectives.
A 2021 survey by MSL Society revealed that 49% of KOLs find scientific updates on new/existing drugs/updates are the most valuable data they acquire during engagements with MSLs (1). This underscores the importance of personalized content in facilitating effective MSL-KOL engagement.
Further, a survey conducted by the MSL Society revealed that 30% of MSL field team members did not know of any barriers to adopting new solutions for personalizing their KOL engagements. This indicates that there is a notable opportunity for MSLs to leverage customized content to enhance their interactions with KOLs.
Personalized content serves as a dual purpose. It addresses medical concerns while also serving as a beacon of hope. By tailoring patient testimonials, success stories, and research insights to align with the interest and concerns of specific patient segments, MSLs can empower and uplift, in addition to informing. Therefore, it is crucial to augment the process of identifying, connecting, and sharing targeted content for effective MSL-KOL engagement.
Enhancing MSL-KOL Engagement: The Integral Role of Digital Tools in Personalized Communication
Digital strategies and tools have transitioned from being mere supportive elements to becoming the backbone of the MSL practice. These tools, including advanced ones like GenAI, are instrumental in enhancing MSL-KOL engagement by facilitating the creation of near real time personalized content tailored to individual KOLs. The main purpose of these tools lies in expanding the reach of MSLs and delivering customized messages, rather than replacing field teams.
The digital tools enable MSLs to distill complex scientific information into easily understandable bite size content, thereby fostering clearer communication with KOLs, and improving retention of information. This not only strengthens the MSL-KOL relationship but also ensures that the most accurate and pertinent information is conveyed, thereby promoting evidence-based decision-making in healthcare.
As we venture into the future, the cutting-edge technologies such as GenAI and Machine Learning (ML) is set to revolutionize the capabilities of Medical Affairs organizations (2). These tools will enable the processing and interpretation of vast data volumes, thereby empowering MSLs to delve deeper into the preferences and needs of KOLs.
In the context of personalized content creation, this technological evolution represents a paradigm shift. The potential of GenAI to transform the landscape is immense. By harnessing the power of GenAI, MSLs can proactively tailor their engagement strategies, ensuring their approach remains not only informed but also relevant.
Challenges and Solutions in Personalized Content Creation
Creating personalized content for effective MSL-KOL engagement is a complex task. The process involves understanding customer data, integrating technology, and maintaining relevance, among other factors. Despite these challenges, the benefits of personalized content, such as increase engagement and customer satisfaction, make it a worthwhile endeavor.
Specific challenges include, but are not limited to:
- Data Collection and Analysis: Personalized content requires a deep understanding of customer data, segmentation, and personalization technology. Collecting and analyzing this data can be a complex and time-consuming process.
- Technology Integration: Integrating personalization technology with existing systems can be a complex task. It requires technical expertise and can involve significant time and resources.
- Generic Digital Content: According to research by McKinsey research, two-thirds of medical professionals complain they are bombarded with generic digital content and are seeking more personalized, tailored, and user-friendly information (3).
- Maintaining Relevance: Personalized content needs to be constantly updated to remain relevant. This requires ongoing data collection and analysis, as well as a flexible content strategy.
- Scalability: Creating a truly personalized experience for every customer can be difficult to scale. It requires sophisticated algorithms and a significant amount of data processing power.
- Lack of Integrated Platform: There can be challenges in implementing modular content, including the lack of an integrated platform for creating scientific and medical modular content that caters to the needs of medical affairs. Careful content planning is needed to identify the required deliverables and key content pieces within them.
These challenges highlight the need for a well-planned and executed personalization strategy.
A Collaborative Approach to Personalized Medical Content Creation
The creation of personalized content is a collaborative effort that requires the expertise and input of various internal stakeholders. The scientific communications team and MSLs play a pivotal role in this process.
The scientific communications team brings their expertise in content creation, understanding of the target audience, and knowledge of the latest trends and technologies in medical communication. On the other hand, MSLs, with their deep understanding of the medical landscape, patient needs, and scientific research, provide valuable insights that guide the content creation process.
This collaboration ensures that the content created is not only scientifically accurate but also tailored to the needs and preferences of the target audience. It enhances the effectiveness of the content, making it more engaging and impactful.
Collaborative opportunities within the medical affairs functions include:
- Content Planning: The scientific communications team and MSLs can work together to plan the content. This includes identifying the key messages, the target audience, and the best channels for dissemination.
- Content Creation: MSLs can provide the scientific expertise needed to create accurate and relevant content. The scientific communications team can then use their skills to present this information in a way that is engaging and easy to understand.
- Content Review: Before the content is disseminated, it can be reviewed by both teams to ensure its accuracy and relevance.
- Feedback and Improvement: Following dissemination of the content, both teams can collaborate to collect feedback and enhance the content. This process may involve analyzing engagement metrics, conducting surveys, or engaging in discussion with the target audience.
- Leveraging Technology: Use technology to deliver personalized content. This could include mobile apps, interactive websites, virtual reality, and more. The choice of technology should be based on the preferences of the HCPs. Provide training to MSLs on omnichannel communication options to confidently assist HCPs in navigating different sources.
- Metrics and Evaluation: Regularly evaluate the effectiveness of the content through metrics such as engagement rates, feedback from HCPs and MSLs, etc. This can provide insights for continuous improvement.
Remember, the goal is to provide HCPs with the information they need in a format that is easy for them to understand and use. This can help in enhancing their knowledge, improving patient care, and ultimately leading to better health outcomes. The future of MSL-KOL engagement hinges on the impact of personalized content and the efficient use of digital tools like GenAI, a goal that can be accelerated through collaboration between scientific communications and MSL teams.
References:
- Key Opinion Leaders Reveal the Value of Medical Science Liaisons. 2021 MSL Society
- Hansjee N, Vitalini E, Ingram J, Turbull J. Moving on from the maybes: Real-life uses of generative AI in Medical Affairs. Innovate, Medical Affairs Professional Society.
- Evers M, Ostojic I, Suresh B, et. al. Medical Affairs: Key imperatives for engaging and educating physicians in a digital world. McKinsey & Company, Article, 2018.
About the authors:

Prem Sundivakkam, PhD, MBA
Prem Sundivakkam, PhD, MBA, a seasoned board-certified medical affairs professional, is renowned for his scientific acumen within the pharmaceutical and medical devices industries. Specializing in oncology, hematology, and rare diseases, he demonstrates a commitment to advancing medical knowledge. His academic credentials, a PhD in Pharmacology and an MBA in Strategy and Leadership, equip him with a unique blend of scientific expertise and business acumen. As a prolific author, he has contributed to 23 highly cited peer-reviewed journals and served on several internationally acclaimed editorial boards. In his leadership role at MAPS, he oversees the Midwest Territory and serves in the Working Group on Medical Insights, fostering cross-industry partnerships and driving innovation. His leadership of the 2023 and 2024 Medical Affairs Technology and Innovation Summits underscores his impact. Recognized with several awards, Dr. Sundivakkam continues to shape the field of medical affairs.

Robin Klasek, PharmD, MPH, BCPS
Takeda Pharmaceuticals
Robin Klasek is an experienced Organ Transplant Clinical Pharmacist based in Boston, MA. In 2021, he transitioned to the role of Medical Science Liaison for Rare Diseases and Transplant, where he demonstrated a profound interest in medical communications and the utilization of advanced technology to enhance messaging. Robin is known for his dedication to cross-functional collaborations and his keen eye for process improvements. Currently, he has embraced a new role in Medical Communications and Scientific Training, continuing to leverage his expertise to drive innovation and excellence in the field.
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