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Listening Between the Lines: Bridging Insight Gaps Post-Regulatory Approval Through Social Media Listening

July 20, 2025
Author(s): Arta Subagiarta, MD, MMSc and Christina Ha, PharmD, MBA

Regulatory approval, be it from the FDA, EMA, or other agencies, is a critical milestone but not the finish line. For Medical Affairs, it marks the beginning of a new challenge: rapidly understanding how treatment is being perceived, questioned, and integrated into practice to benefit patients and communities. While internal teams prepare launch materials and field strategies, critical conversations begin to unfold almost immediately in public digital spaces.

Healthcare professionals (HCPs) share early clinical impressions, patients discuss expectations, and digital opinion leaders (DOLs) shape emerging scientific narratives. These interactions are candid, unfiltered, and occur in real-time, often preceding traditional insight-gathering mechanisms such as field engagement or advisory boards.

Social media listening offers a complementary and immediate outlook, providing Medical Affairs with an ‘always-on’ lens to capture early signals, unmet needs, and perceptions that inform timely strategic decisions.

From Data to Direction

At the core of every medical strategy lies a simple imperative: stay aligned with the evolving needs of patients, HCPs, and the broader healthcare landscape. Upon launch, real-time social media insights help us to quickly gauge sentiment. These early insights reveal what excites HCPs, what questions they have, and how they view the newly approved therapy’s impact on patient care. If enthusiasm is low, HCP online commentary can help identify if this is due to factors such as safety concerns, access issues, or data misconceptions.

When thoughtfully integrated, social media insights supplement existing feedback channels, offering accelerated feedback loops and early visibility into evolving HCP and patient perspectives. Such early insights are invaluable for shaping launch-directed initiatives across cross-functional teams.

These insights enable field medical teams to tailor their interactions to reflect emerging real-world topics, ensuring Medical Science Liaisons (MSLs) are well-prepared to address questions or clarify any data misunderstandings. By following up during their engagements, MSLs can delve deeper into the reasons behind online HCP viewpoints. Monitoring HCPs online allows MSLs to better understand their stakeholders and engage with them in a more personalized manner. Recognizing HCP motivations for engaging online, whether to educate or expand their network, can guide effective Medical Affairs collaboration. Additionally, social listening helps identify new influential stakeholders and rising stars for future engagement.

The value of social media listening extends beyond the launch phase. It should be viewed as an ongoing, proactive activity throughout the product’s lifecycle. By monitoring the evolving social narrative within a disease state, teams can stay informed about changes in the therapeutic landscape and implications on clinical practice.

Social listening is not only about collecting insights; it’s about translating this data into actionable strategies. To harness the full potential of social listening, we need to transition from passive monitoring to active integration. Digital insights should be curated with scientific rigor and contextual understanding and embedded into key activities across the medical ecosystem.

Potential integration points include:

  • Field engagement: prioritize topics and address objections based on trending conversations
  • Medical content: adapt core materials, FAQs, and training to reflect real-world discussions
  • Training: equip teams with examples and language grounded in current dialogues
  • Scientific communication: identify evidence gaps to guide real-world evidence (RWE) or health economics and outcomes research (HEOR) initiatives
  • External expert identification: recognize emerging digital voices and community influencers shaping clinical perceptions.

As companies adapt their strategies based on insights, social media can be used to measure the impact of these updated tactics on meeting objectives, allowing for continuous refinement of approaches.

From Volume to Value

Keeping up with the continuous influx of social media data can be challenging. Relying on manual social media monitoring through self-tracking key terms, hashtags, and accounts can be cumbersome and inefficient due to overwhelming data volume and potential noise. This is where social media listening platforms that utilize natural language processing come into play. These powerful tools provide a more precise and targeted approach, allowing users to sift through data from multiple social media sources simultaneously. Users can filter and sort information by time frames, relevant topics, or audience segments, making it easier to organize insights according to predefined listening priorities and strategic questions.

Utilizing automatic notifications or reporting tools available through social listening platforms can alert teams to significant changes in activity within monitored topics or disease areas. These approaches ensure that critical insights are never missed and allow for agile responses to emerging real-world signals.

Challenges, Cautions, and the Road Ahead

While engaging in social media listening, teams should adhere to their company’s corporate social media policies, local regulations, and data privacy guidelines. Teams should coordinate with their communications department for managing misinformation or negative narratives. Additionally, it is crucial to follow pharmacovigilance reporting requirements for any mentions of adverse events, misuse, abuse, or off-label usage.

While powerful, social media listening comes with its challenges. Posts may lack context, certain perspectives may be overrepresented, and interpretation requires a careful balance between data and discernment. Key considerations include:

  • Representativeness and bias: Not all HCPs or patients are active online
  • Interpretation: Necessitates domain expertise and human review to validate and avoid misinterpretation
  • Privacy and ethics: Navigating these spaces responsibly within company guidelines is paramount

Despite these challenges, the cost of disregarding digital conversations is substantial. Forward-looking Medical Affairs teams should consider initiating small-scale pilots, forming cross-functional task forces, and establishing structured governance to evaluate feasibility.

Conclusion

In an era where initial clinical impressions of new therapies may surface on social media before appearing in peer-reviewed journals, the opportunity for Medical Affairs to listen and act has never been greater. Social media listening is not about replacing traditional insight collection but enhancing and accelerating it. By capturing what matters in the moment, Medical Affairs can ensure strategies remain timely, patient-centered, and scientifically aligned.

About the author:

Arta Subagiarta, MD, MMSc

Arta is an Associate Medical Director at Sanofi with a diverse background in clinical medicine, academia, startup leadership, and both global and U.S. pharma. As a former co-founder of a multimillion-dollar health-tech startup, he brings a unique lens to medical affairs. At Sanofi, he drives innovation through scalable, patient-centered solutions that blend science, digital tools, and strategic insight. He has led cross-functional efforts in medical strategy, field engagement, and capability building, all fueled by a passion for turning science into real-world impact.

Christina Ha, PharmD, MBA

Christina is a Global Medical Omnichannel Capabilities Lead at Sanofi, where she drives the continuous enhancement and glocal implementation of digital tools and strategies that empower Medical Affairs teams. With a strong foundation in field medical affairs and digital innovation, Christina has led data-driven initiatives in social media listening, Digital Opinion Leader engagement, and medical insights generation.

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